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KMID : 1149220020100010169
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Korean Journal of Oriental Medical Prescription
2002 Volume.10 No. 1 p.169 ~ p.180
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Effects of Radix Puerariae, Flos Puerariae and Bamboo+Radix Puerariae Water Extracts on the Ethanol-administered Mice
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Kim Kyung-Soo
Jeong Jong-Kil
Na Chang-Su
Kim Jeong-Sang
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Abstract
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This study was performed to investigate the effects of Radix Puerariae (RP), Flos Puerariae (FP) and Caules in Liquamen Phyllostachyos+Radix Puerariae water extracts on the alcohol dehydrogenase (ADH). transaminase (GOT, GPT) activities, and two hepatic antioxidant enzyme (SOD, catalase) activities in acute ethanol administered mice, and we have investigated the morphological changes that occur in hepatocytes of the experimental mice. The activities of ADH decreased compared with control group in the A1(66%), C1(57%), C2(54%) groups. The transaminase activites increased in the control groups compared with experimental groups. Ethanol treatment group without the RP or FP administration significantly lowered the activities of hepatic SOD and catalase, whereas MnSOD increased in the A1(27%) and B2(43%)groups, CuZnSOD increased in the B2(25%) and C2 groups. The catalase activites were increased in the A1(270%), A2(478%), B2(487%) and B1(770%) compared with control group, A lot of PAS-positive granules were observed in the A1, A2, C1 and C2 groups compared with the other groups. These results suggested that RP, FP and RP+Bamboo extracts administration may be prevent from liver damage in the alcohol treatment mice.
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KEYWORD
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Radix Puerariae, Flos Puerariae, Bamboo extract+Radix Puerariae, transaminase, antioxidant enzyme, AS-immunohistochemistry
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